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Methods and uses of fibronectin type III domain based on composition structures

机译:基于组成结构的纤连蛋白III型结构域的方法和用途

摘要

An isolated protein structure comprising an amino acid sequence that has at least 75% identity of SEQ ID NO: 16, which has 7 strains and 6 loops between the strains, and which comprises the amino acid sequence SEQ ID NO: 16, but in which one or more of the loops are altered to bind to a target while the strains maintain their sequence as trunk portions, in which the loops are in residues 13-16, 22-28, 38-43, 51-54, 60-64 and 75-81 of SEQ ID NO: 16 and are capable of binding with cellular proteins and / or nucleic acid molecules.
机译:一种分离的蛋白质结构,其包含与SEQ ID NO:16具有至少75%同一性的氨基酸序列,其具有7个菌株和菌株之间的6个环,并且包含氨基酸序列SEQ ID NO:16,但是其中改变一个或多个环以结合至靶标,同时菌株将其序列保持为树干部分,其中环位于残基13-16、22-28、38-43、51-54、60-64和SEQ ID NO:16的75-81,并且能够与细胞蛋白和/或核酸分子结合。

著录项

  • 公开/公告号ES2595504T3

    专利类型

  • 公开/公告日2016-12-30

    原文格式PDF

  • 申请/专利权人 JANSSEN BIOTECH INC.;

    申请/专利号ES20090824067T

  • 发明设计人 JACOBS STEVEN;ONEIL KARYN;

    申请日2009-10-27

  • 分类号C40B30/04;C07H21/04;C07K7/06;C07K14;

  • 国家 ES

  • 入库时间 2022-08-21 13:35:32

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