Novel octahydrothienoquinoline derivative, pharmaceutical composition comprising the derivative, and use thereof

摘要

A compound represented by the general formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein R1 is any one of the following a) to d): a) a cyano group, b) a carbamoyl group, c) a C2-C7 alkoxycarbonyl group, or d) a carboxy group; R2 and R3 are each independently a hydrogen atom, a C1-C6 alkyl group, a C1-C7 acyl group, or a (C2-C7) alkoxy carbonyl group; R4 is a hydrogen atom, a C1-C6 alkyl group, or a C1-C6 haloalkyl group; R5 is any one of the following a) to j): a) a C1-C6 alkyl group, b) a C1-C6 haloalkyl group, c) a cycloalkyl group, d) a benzofused cycloalkyl group, e) a C1- cycloalkylalkyl group C6, f) an aralkyl group, wherein the ring of the aralkyl group is unsubstituted or substituted with 1 to 5 substituents selected independently from the group consisting of a halogen atom, a C1-C6 alkyl group, a C1- haloalkyl group C6, a C1-C6 alkoxy group, and a C1-C6 hydroxyalkyl group, g) a C1-C6 heteroarylalkyl group, wherein the ring of the C1-C6 heteroarylalkyl group is unsubstituted or substituted with 1 to 3 substituents selected independently of the group consisting of a C1-C6 alkyl group, a C1-C6 haloalkyl group, and a C1-C6 alkoxy group, h) a C2-C6 alkenyl group, i) a C1-C6 alkoxy group C1-C6, or j) a R10R11N-C1-C6 alkyl group; R6 and R7 are each independently any one of the following a) to k): a) a hydrogen atom, b) a C1-C6 alkyl group, c) a C1-C6 haloalkyl group, d) a heterocycloalkyl group, e) a C1-C6 heterocycloalkylalkyl group, f) an aralkyl group, wherein the ring of the aralkyl group is unsubstituted or substituted with 1 to 5 substituents selected independently from the group consisting of a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, a C1-C6 alkoxy group, and a R10R11N-C1-C6 alkyl group, g) a C1-C6 heteroarylalkyl group, wherein the ring of the C1-C6 heteroarylalkyl group is unsubstituted or substituted by 1 to 3 substituents independently selected from the group consisting of a C1-C6 alkyl group, a C1-C6 haloalkyl group, and a C1-C6 alkoxy group, h) a C1-C6 alkoxy group, C1-C6 alkyl,