Procedure for reducing ketones derived from continuous vitamin d and calcipotriol manufacturing process and corresponding use (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for reducing ketones derived from continuous vitamin d and calcipotriol manufacturing process and corresponding use. Procedure for reducing ketones derived from vitamin d of general structure (V) or (VI) with borohydrides, where r1 and r2 may be the same or different and represent hydrogen or hydroxyl protecting groups, to give compounds of general structure (III) and (IV) or (VII) and (VIII), useful as intermediates for the synthesis of calcipotriol, where the reduction reaction is carried out in a continuous flow reactor. This procedure can be used as part of a calcipotriol manufacturing process. (Machine-translation by Google Translate, not legally binding)