Folate alpha receptor as diagnosis and prognosis for marker folate receptor of alpha-expressing cancers

摘要

A method of assessing whether a subject is affected with a Cancer expressing FRα, the method comprising determining the level of folate receptor alpha (Frα) that is not bound to a cell, in a urine sample derived from said subject; and compare the level of alpha folate receptor (Frα) that is not bound to a cell with the level of FRα in a control sample, in which a difference between the level of FRα in the urine sample derived from said subject and the level of FRα in the control sample is an indication that the subject is affected with a cancer that expresses FRα; wherein the level of FRα that is not bound to a cell in the urine sample derived from said subject is evaluated by contacting the sample with an antibody that binds FRα.