Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents

摘要

#$%^&*AU2017200159A120170202.pdf#####H:dxjrnvloveroaRPorthlD(CCRBR l2724126_lIocx-10/i]/2017 ABSTRACT This invention is directed to pharmaceutical compositions for topical administration to a mammal, wherein the pharmaceutical compositions comprise a spiro-oxindole compound, 5 as an enantiomer, a racemate or a non-racemic mixture, or a pharmaceutically acceptable salt thereof. These pharmaceutical compositions are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions.WO 2011/106729 PCT/US20111026359 1/5 Percent Change fror Baseline in CFA Model 6040 20 F -20L/ FIGURE