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SINGLE-GUIDE RNA (SGRNA) WITH IMPROVED KNOCKOUT EFFICIENCY
SINGLE-GUIDE RNA (SGRNA) WITH IMPROVED KNOCKOUT EFFICIENCY
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机译:单导RNA(SGRNA),提高了敲除效率
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摘要
The present invention includes a modified single-guide RNA (sgRNA) template with improved knockout efficiency specific for a target gene comprising an sgRNA construct comprising at least one of a mutated duplex region wherein a length of the duplex region is extended, or a mutated poly T region at the beginning of the duplex region, wherein the sgRNA has a greater target gene knockout efficiency in cells.
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