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ACTIVATION OF T CELLS WITH INCREASED PLASMA MEMBRANE CHOLESTEROL LEVELS
ACTIVATION OF T CELLS WITH INCREASED PLASMA MEMBRANE CHOLESTEROL LEVELS
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机译:血浆膜胆固醇水平升高激活T细胞
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摘要
The present invention provides methods and compositions for activating a CD8+ T cell which is useful for cancer immunotherapy and treating infections. The CD8+ T cell can be activated by contacting with an agent that increases the plasma membrane cholesterol level of the cell. Also provided are methods and agents for screening for agents useful for inhibiting CD8+ T cells.
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