PLASMID EXPRESSION VECTOR ENCODING HUMAN INTERLEUKIN 12 UNDER TRANSCRIPTIONAL CONTROL OF P21 PROMOTER AND WITHOUT ANTIBIOTIC RESISTANCE FOR CANCER GENE THERAPY AND OTHER USES THEREOF

摘要

The present invention relates to an expression plasmid comprising a polynucleotide encoding an IL-12 (Interleukin 12) polypeptide and operably linked thereto a CDKN1A promoter, wherein said expression plasmid does not comprise a selectable marker gene. The expression plasmid can be used for the treatment of cancer.