The present invention relates to a compound of formula (I), or a pharmaceutically acceptable acid addition salt thereof, a racemic mixture, or a corresponding enantiomer and / or optical isomer thereof: (I) In this formula, R 1 is hydrogen, lower alkyl, halogen, or lower alkyl substituted by halogen; R 2 is hydrogen or halogen; X 1 is N or CH, X 2 is N or CH, Only one of X 1 and X 2 is N; X 3 is C (R) or N; R is hydrogen, substituted by lower alkyl, halogen, halogen lower alkyl, lower alkoxy or SO 2 - is lower alkyl. The compounds are useful for the treatment of schizophrenia, compulsive personality disorder, major depression, bipolar disorder, anxiety disorder, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post traumatic stress disorder, panic disorder, Parkinson's disease, Chronic cognitive impairment, chronic cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autistic spectrum disorders, hearing loss, tinnitus, spinal cord cerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, Can be used to treat the abuse of active drugs such as alcohols, opiates, methamphetamine, phencyclidine and cocaine.
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