The present invention relates to compounds of general formula wherein R1 hydrogen, lower alkyl, halogen or lower alkyl substituted by halogen; R2 is hydrogen or halogen; X1 is N or CH; X2 is N or CH; with the proviso that only one of X1 or X2 is N; X3 is C(R) or N; and R is hydrogen, lower alkyl, halogen, lower alkyl substituted by halogen, lower alkoxy or SO2-lower alkyl; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.
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机译:本发明涉及通式为R 1的氢,低级烷基,卤素或被卤素取代的低级烷基的通式化合物; R 2是氢或卤素; X1是N或CH; X2为N或CH;前提是X1或X2中只有一个为N; X3是C(R)或N; R是氢,低级烷基,卤素,被卤素取代的低级烷基,低级烷氧基或SO 2-低级烷基;或其药学上可接受的酸加成盐,外消旋混合物或其相应的对映异构体和/或其旋光异构体。该化合物可用于治疗精神分裂症,强迫性人格障碍,重度抑郁症,躁郁症,焦虑症,正常衰老,癫痫,视网膜变性,脑外伤,脊髓损伤,创伤后应激障碍,恐慌症,帕金森氏病,痴呆,阿尔茨海默氏病,轻度认知障碍,化学疗法诱发的认知功能障碍,唐氏综合症,自闭症谱系障碍,听力损失,耳鸣,脊髓小脑共济失调,肌萎缩性侧索硬化症,多发性硬化症,亨廷顿舞蹈症,中风,放射疗法,慢性压力,滥用神经活性药物,例如酒精,鸦片,甲基苯丙胺,苯环利定和可卡因。
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