COMPOSITION FOR DIFFERENTIATION OF SKIN CELLS AND METHOD FOR SCREENING FOR MATERIALS FOR PROMOTING DIFFERENTIATION OF SKIN CELLS

摘要

In this specification, a method for screening a composition for promoting differentiation of skin cells and a skin cell differentiation promoting substance is disclosed. The composition for promoting differentiation of skin cells of the present invention inhibits the expression or activity of JAB-1, and as a result, the movement of the cephalosporin into the cell nucleus is inhibited, and skin cell differentiation can be effectively promoted. The present invention also provides a method for screening a skin cell differentiation-promoting substance according to an aspect of the present invention, which comprises treating a keratinocyte with a test substance and measuring the relative expression of JAB-1 The keratinocyte differentiation promoting substance can be screened easily, promptly and efficiently.