1 Composition for treatment or prevention of autoimmune diseases comprising PTEN-induced kinase 1 protein or nucleotide

摘要

The present invention relates to a composition for preventing or treating autoimmune diseases, which comprises a PINK 1 protein or a polynucleotide encoding the same as an active ingredient. The PTEN-induced kinase 1 (PINK1) protein according to the present invention inhibits the activity of Th17, promotes the activity of regulatory T cells (Treg), increases autophagy in Treg cells And thus can be usefully used as a pharmaceutical composition or immunosuppressive agent capable of preventing or treating autoimmune diseases caused by abnormalities of various immune responses such as arthritis.