siRNA Method of producing a tumor specific siRNA delivery system containing gold nano particles

摘要

The present invention relates to a method of preparing an siRNA delivery vehicle, and more particularly, to a method for preparing siRNA delivery system, comprising: a first step of reacting a cationic polymer and siRNA to form a complex of a cationic polymer and siRNA; A second step of reacting the complex with an aqueous chloride solution; And a third step of reacting the reaction product of the second step with polyethyleneglycolated hyaluronic acid. The present invention also relates to a method for producing a cancer cell-specific siRNA delivery system.A first layer comprising a complex of cationic polymer and siRNA, and gold nanoparticles; And a second layer containing polyethylene glycolized hyaluronic acid modified on the surface of the first layer.