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sugar chemical compound-taxane compound A pharmaceutical composition for preventing or treating cancer comprising sugar chemical compound-taxane compound conjugate and a method for preparation thereof
sugar chemical compound-taxane compound A pharmaceutical composition for preventing or treating cancer comprising sugar chemical compound-taxane compound conjugate and a method for preparation thereof
The present invention relates to a pharmaceutical composition for preventing or treating cancer comprising, as an active ingredient, a drug conjugate of a taxane compound having a carboxy group and a sugar compound having a hydroxy group, Reacting a taxane compound having a hydroxyl group with a sugar compound having a carboxyl group in the presence of 4-dimethylaminopyridine and N, N'-dicyclohexylcarbodiimide, , A method for producing a drug conjugate, and a carboxymethyl dextran-docetaxel polymer conjugate represented by Chemical Formula (1).The drug conjugate of the present invention is capable of releasing a taxane compound by hydrolysis of an ester bond in the conjugate in a mildly acidic environment in a cancer microenvironment. Since no enzymes are required in the above process, it can be used effectively as a cancer treatment agent which minimizes side effects by selectively releasing taxane compounds at cancer lesion sites which are not normal tissues.;
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