PROCESS FOR OBTAINING OLOPATADINE AND INTERMEDIATES

摘要

To may give the OLLO Zapata Dean through a process comprising the hydrolysis of a compound of formula (II), and Y is OR ₁ wherein R, in which R ₁ is C ₁ ~ C ₇ alkyl, C ₃ ~ C ₇ Cycloalkyl, aryl, arylalkyl, or heterocycle; Or NR ₂ R ₃ wherein R ₂ and R ₃ are independently of each other C ₁ -C ₇ alkyl, aryl, arylalkyl or R ₂ and R ₃ together with the nitrogen atom to which they are attached form a 3-7 membered heterocycle Lt; / RTI Reacting a corresponding ester or amide of 6,11-dihydro-11-oxodibenz [ b, e ] oxepin-2-acetic acid with a suitable Wittig reagent in the presence of a base in a reaction medium comprising an organic solvent / RTI [Formula (II)]