Composition for preventing or treating asthmatic disease comprising monoacetyldiacylglycerol compound

摘要

The present invention relates to a pharmaceutical composition containing a mono acetyl diacyl glycerol compound as an active ingredient for preventing or treating asthma, and a health functional food composition for preventing or ameliorating asthma. The mono acetyl diacyl glycerol compound of the present invention inhibits the expression of IL-4 in EL-4 cells, which are mouse T cell lymphoma cells, alleviates airway hyperreactivity in asthma-inducing animal models, and suppresses infiltration of inflammatory cells into the bronchi . In addition, the compounds of the present invention are excellent in the effect of inhibiting IgE production in serum and bronchoalveolar lavage fluid and inhibiting the expression of Th2 cytokines (IL-4, IL-5 and IL-13) The present invention relates to a composition for preventing, treating, and ameliorating asthma, which is excellent in therapeutic effect without toxicity.