Method and kit for diagnosis of tuberculosis based on Mycobacterium tuberculosis antigen-specific antibody reaction

摘要

We use a specimen-specific response to a combination of antigens selected from 38 kDa, 16 kDa, ESAT-6, CFP-10 and LAM antigens to distinguish between active, latent or recurrent tuberculosis, A method and kit for diagnosing or detecting whether a specimen judged to be negative in smear test is active tuberculosis is disclosed. The method or kit according to the present invention can be diagnosed as having high sensitivity and specificity for the diagnosis of active tuberculosis, latency tuberculosis, or recurrent tuberculosis, which is difficult to diagnose by the conventional methods, Together with the smear method, the tuberculosis can be accurately and quickly identified.