PCV2Porcine Circovirus type2 Method for mass production of PCV2 vaccine and vaccine composition using the same

摘要

The present invention relates to a method for mass production of PCV2 vaccine using the ORF2 gene of codon-optimized PCV2 (Porcine Circovirus type 2), a vaccine composition for preventing PCV2 infection using the same, and a method for preventing PCV2 infection disease by administering the vaccine composition to pigs . When the ORF2 gene of the codon-optimized PCV2 according to the present invention is used, the expression level in the insect cells is increased up to 10 times as compared with the case of using the ORF2 gene of the normal PCV2. Thus, the PCV2 vaccine can be mass-The vaccine composition prepared by the above method is excellent in antibody production ability and virus defense ability and can be useful for prevention of PCV2 infection diseases.;