-CD40 LYOPHILISED AND AQUEOUS ANTI-CD40 ANTIBODY FORMULATIONS

摘要

The anti-CD40 antibody is formulated as a lyophilisate or a liquid preparation. The lyophilizate can be reconstituted to provide a solution having a high concentration of the antibody active ingredient for delivery to the patient without high levels of antibody aggregation. The lyophilizate may be reconstituted with an aqueous reconstitution component to provide an aqueous composition wherein the antibody has a concentration of at least 50 mg / ml. The lyophilizate or aqueous pharmaceutical composition may comprise one or more of sugars, buffers, surfactants and / or free amino acids.