/ Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids

摘要

The present invention relates to novel polymeric carrier molecules according to general formula (I) which enable the efficient transfection of nucleic acids into cells in vivo and in vitro, their modified products, nucleic acid and polymeric carrier delivery made by unique polymeric carrier molecules Water complex, as well as to a process for the preparation of such unique polymeric carrier molecules and a process for the preparation of unique polymeric carrier-delivery complexes. The present invention also provides methods and uses of such unique polymer carrier molecules and unique polymeric carrier delivery complexes in the preparation of pharmaceutical compositions for the treatment of various diseases and for the treatment of such diseases as medicaments .