STABLE injectable pharmaceutical compositions containing epinephrine OR ITS SALTS

摘要

1. Stabilized pharmaceutical composition injectable epinephrine or a salt thereof containing sodium metabisulfite, wherein the ratio of the amount of epinephrine or its salt to sodium metabisulphite in the composition is from about 1: 0,005 to about 1: 1.5 by weight, characterized in that said composition It contains epinephrine having a purity equal to or greater than 98% by masse.2. Stabilized pharmaceutical composition epinephrine injection, containing sodium metabisulfite, wherein the ratio of the amount of epinephrine or its salt to sodium metabisulphite in the composition is from about 1: 0,005 to about 1: 1.5 by weight, wherein the total amount of impurities in said composition is less than 4% .3. Stabilized pharmaceutical composition epinephrine injection, containing sodium metabisulfite, wherein the ratio of the amount of epinephrine or its salt to sodium metabisulphite in the composition is from about 1: 0,005 to about 1: 1.5 by weight, characterized in that said composition contains no one impurity in an amount exceeding 3% .4. The stabilized injectable pharmaceutical composition epinephrine or a salt thereof containing sodium metabisulfite, wherein the ratio of the amount of epinephrine or its salt to sodium metabisulphite in the composition is from about 1: 0,005 to about 1: 1.5 by weight, characterized in that said composition is substantially It contains excess epinefrina.5. The stabilized injectable pharmaceutical composition according to Claim. 1, wherein the composition comprises a sulphonate epinephrine in an amount of about 3.0% or less at SVA 0,15.6. The stabilized injectable pharmaceutical composition according to Claim. 1,