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COMPOSITION BASED ON R(-)-PRAZIQUANTEL FOR TREATING AND PREVENTING HELMINTHIASIS IN WARM-BLOODED ANIMALS
COMPOSITION BASED ON R(-)-PRAZIQUANTEL FOR TREATING AND PREVENTING HELMINTHIASIS IN WARM-BLOODED ANIMALS
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机译:基于R(-)-PRAZIQUANTEL的组合物用于预防和预防温血动物的蠕虫病
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摘要
FIELD: pharmaceutics.;SUBSTANCE: invention refers to pharmaceutics and can be used for treating and preventing helminthiasis in warm-blooded animals, including agricultural and domestic animals, in particular cats and dogs. For this anthelminthic composition is proposed containing as an active agent combination of praziquantel enantiomer (R-praziquantel, R-PZQ), presented in the form of complex with beta-cyclodextrin, and pyrantel pamoat, as well as water and vegetable oil, neutral filler and auxiliary additives, particularly additive with hepatoprotective and GIT microflora recovering action in following proportions (wt%): R-praziquantel 0.1–0.5, pyrantel pamoat 1.0–3.0, beta-cyclodextrin 1.5–5.0, fillers and auxiliary additives 1.2–5.3, vegetable oil 4.0–22.0, water – rest. Proposed water-oil suspension is characterized by wide spectrum of action, storage stability, ease of use, texture and taste, acceptable for animals, and differs from known analogues in higher efficacy of cystocidal action, achieved due to possibility of 2-5-fold reduction of effective dose of R(-)-praziquantel in comparison with conventionally used racemic mixture.;EFFECT: invention provides improved consumption by animals, including any kinds of dogs, kittens and puppies, as well as aged and/or debilitated animals.;6 cl, 9 tbl, 5 ex
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