quinazoline derivative, pharmaceutical composition, use of a quinazoline derivative, methods to produce an anti-proliferative effect in a warm-blooded animal, to prevent or treat tumors in a warm-blooded aminal, to provide a tyrosine kinase inhibitory effect of selective egfr in a warm-blooded animal and to treat cancer in a warm-blooded animal and process for the preparation of a quinazoline derivative

摘要

"QUINAZOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION, USE OF A QUINAZOLINE DERIVATIVE, METHODS TO PRODUCE ANTI-PROLIFERATIVE EFFECT ON A HOT BLOOD ANIMAL, FOR PREVENTION OR TREATMENT OF TUMORS IN A FIBER BLOOD ANIMAL, AND SELECTIVE EGFR TYROSINE KINASE IN A HOT BLOOD ANIMAL AND TO TREAT A CANCER IN A HOT BLOOD ANIMAL, AND, PROCESS FOR PREPARING A QUINAZOLINE DERIVATIVE ". The invention relates to quinazoline derivatives of Formula (I) wherein each of R¬1¬, R¬2¬, W, X¬1,, X¬2¬, Z, a and b are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an antiproliferative effect. The quinazoline derivatives of Formula (I) are expected to be useful in the treatment of diseases such as certain erbB receptor tyrosine kinase-mediated cancers, particularly EGFR tyrosine kinase.