APPLICATION OF ADAMANTANE INDOLE AND THEIR HYDROCHLORIDES AS CHOLINESTERASE INHIBITORS AND NMDA-RECEPTORS BLOCKERS

摘要

FIELD: pharmacology.;SUBSTANCE: invention relates to application of adamantane-containing indoles and their hydrochlorides of general formula ; where R₁, R₂, R₃, R₄ may be the same or different and independently represent H, F, Cl, Br, (C₁-C₆) alkyl, (C₁-C₆) alkoxy; R₅, R₆ may be the same or different and independently represent H, (C₁-C₆) alkyl, ONO₂; X representsCH₂CH(OH)CH₂ or CH₂CH₂C(O); Z=no, Cl; R₇, R₈, R₉, R₁₀ may be the same or different and independently represent H, F, Cl, Br, (C₁-C₆) alkyl, (C₁-C₆) alkoxy; R₁₁, R₁₂, R₁₃, R₁₄, R₁₅, R₁₆, R₁₇, R₁₈ may be the same or different and independently represent H, (C₁-C₆) alkyl, as a cholinesterase inhibitors and NMDA receptors blockers, and can be used as new drugs that interact with several targets responsible for improval of memory and cognitive functions, weakening of which has various origin, including dementias of various origins, especially due to neurodegenerative diseases, such as Alzheimer's disease.;EFFECT: increased compound application effeciency.;15 cl, 1 dwg, 1 tbl, 3 ex