METHOD FOR NUCLEOSOMES ADDUCTS DETECTION

摘要

FIELD: pharmacology.;SUBSTANCE: use of a nucleosome-protein adduct as a biomarker in a blood, serum or plasma sample for cancer diagnosis, where the protein bound to a nucleosome contains a transcription factor or a chromatin-modifying enzyme, is proposed. Also, the possibility of cancer detection or diagnosis in an individual, individual assessment regarding the applicability of medical treatment and monitoring of individual treatment are proposed.;EFFECT: ability to diagnose cancer, such as: colon cancer, lung cancer, pancreatic cancer, breast cancer, prostate cancer, by measuring the level of circulating extracellular adducts of nucleosome-HMGB-1 and nucleosome-EZH2 in a biological blood serum or plasma sample, derived from the individual.;20 cl, 11 dwg, 12 ex