Tranquilizer drug chlormezanone synthesis mehtod

摘要

Abstract The present invention discloses tranquilizer drug chlormezanone synthesis method by 2-(3-chloro-1,2-dihydroxyphenyl)-3-methyl-1,3-hydrosothiazin-4-one 5 solution, chloromethyl methyl ether solution were added to the reaction vessel, controlled the stirring rate, controlled the solution temperature, added 2-methyl-2,4-pentanediol solution, added potassium ruthenate in batches, continued to react; reduced the solution temperature, added the potassium carbonate solution in batches, addition time was controlled, the solution was stratificated, removed the oil 10 layer, added benzenesulfonic acid solution, adjusted the pH, extracted with hexafluorobenzene solution several times, extracted with the dimethyl phosphate solution several times, washed with the o-dibromobenzene solution, recrystallized in the polypropylene glycol solution, dehydrated with the dehydrating agent, got the finished product chlormethazone.