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PRODUCTION OF ANTIBODIES WITH IMPROVED GLYCOSYLATION PATTERN
PRODUCTION OF ANTIBODIES WITH IMPROVED GLYCOSYLATION PATTERN
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机译:糖基化模式改善的抗体生产
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摘要
An improved system for large scale production of antibodies in cell culture is provided. In accordance with the present invention, cells expressing an antibody are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a system allows production of an antibody with an increased glycosylation pattern and/or a glycosylation pattern that more accurately reflects the glycosylation pattern of the naturally occurring antibody. An antibody expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical compositions.
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