CHIRAL DIACYLHYDRAZINE LIGANDS FOR MODULATING EXPRESSION OF EXOGENOUS GENES VIA ECDYSONE RECEPTOR COMPLEX

摘要

PROBLEM TO BE SOLVED: To provide diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems.SOLUTION: There is provided a compound represented by formula 1, or a pharmacologically acceptable salt, hydrate, crystalline form or amorphous form thereof. (A is alkoxy, arylalkyloxy or aryloxy; B is optionally substituted aryl or optionally substituted heteroaryl; and R1 and R2 are independently optionally substituted alkyl, arylalkyl, hydroxyalkyl, haloalkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted heterocycle, aryl or heteroaryl.)SELECTED DRAWING: Figure 1