ORAL COMPOSITION HAVING INHIBITORY ACTIVITY OF RETINAL GANGLION CELL DEATH

摘要

PROBLEM TO BE SOLVED: To provide a composition having inhibitory activity of retinal ganglion cell death, and application as a retinal ganglion cell death inhibitor or a glaucoma preventive agent of the composition.;SOLUTION: Retinal ganglion cell death caused by optic nerve disorder is inhibited by orally administering salt of orotic acid or orotic acid. In the case of ingesting as beverage, water-soluble salt such as choline salt, lysine salt, arginine salt, or ornithine salt is preferable. In the case of ingesting as supplement in a capsule, a tablet or the like, salt may be metal salt such as hardly soluble sodium salt, potassium salt, magnesium salt, calcium salt, or ammonium salt. Further, orotic acid can form salt together with carnitine to be solubilized.;SELECTED DRAWING: None;COPYRIGHT: (C)2018,JPO&INPIT