Physiological significance of Rag1 in retinal ganglion cell death

摘要

Although the transcription factor,nuclear factor-κB(NF-κB)is known to regulate cell death and survival,its precise role in cell death within the central nervous system(CNS)remains unknown.We previously reported that mice with a homozygous deficiency for NF-κBp50 spontaneously developed optic neuropathy.We examined the expression and activation of pro-apoptotic factor(s)