Anti-VEGFR2 human antibody for anti-angiogenesis and targeted cancer therapy

摘要

Disclosed is an isolated antibody or antigen-binding fragment thereof having specific binding affinity for an epitope located within domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74). The epitope within domain 3 of VEGFR2 is located between amino acid residues 250 to 270 of SEQ ID NO: 74. Also disclosed is the use of an antibody or antigen-binding fragment thereof in the manufacture of a medicament that inhibits and / or induces them in a subject in need thereof that inhibits tumor growth, tumor angiogenesis and / or induces cytotoxicity against cancer cells. To do. Also disclosed is a method for detecting the presence of VEGFR2 in tumor vascular endothelial cells or cancer cells of a biological sample.