Anti-VEGFR2 human antibodies for anti-angiogenesis and targeted cancer therapy

摘要

Disclosed are isolated antibodies or antigen-binding fragments thereof having a specific binding affinity for an epitope located within domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74). The epitope inside domain 3 of VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. In the manufacture of a medicament for inhibiting / inhibiting tumor growth, tumor angiogenesis or inducing cancer cell cytotoxicity in a subject in need of tumor growth, inhibition of tumor angiogenesis and / or induction of cancer cell cytotoxicity, The use of the antibody or antigen-binding fragment thereof is also disclosed. Also disclosed is a method for detecting the presence of VEGFR2 in tumor vascular endothelial cells or cancer cells in a biological sample.