Process for preparing low ABUK oxymorphone hydrochloride

摘要

An improved method for the preparation of oxymorphone hydrochloride containing less than 10 ppm 14-hydroxymorphinone is provided. Oxymorphone hydrochloride is a process in which a starting material containing oxymorphone base and 14-hydroxymorphinone is hydrogenated in a mixture containing alcohol, water and acid, a portion of the water is removed, and additional alcohol is added to the mixture. It is produced | generated by the process to do. [Selection] Figure 1