METHODS AND APPARATUS FOR DETECTION OF GLUTEN SENSITIVITY AND DIFFERENTIATION BETWEEN GLUTEN SENSITIVITY AND CELIAC DISEASE

摘要

PROBLEM TO BE SOLVED: To provide methods of using antibodies as biomarkers to distinguish gluten immune reactivity and gluten sensitivity, silent celiac disease, Crohn's disease and other gut-related diseases from classical celiac disease.;SOLUTION: Sera, saliva or other samples from a human or other animal are tested for antibodies to (a) a wheat antigen, (b) a gliadin antigen, and (c) one or more of a wheat germ agglutinin, a gluteomorphin, a glutenin, a deamidated glutenin, a prodynorphin, and a dynorphin. The wheat antigen and the gliadin antigen are both selected from the group consisting of an α-gliadin-33-mer, an α-gliadin-17-mer, a γ-gliadin-15-mer, an ω-gliadin-17-mer, and a glutenin-21-mer.;SELECTED DRAWING: Figure 7;COPYRIGHT: (C)2018,JPO&INPIT