System and method for detection and treatment of disease exhibiting disease cell heterogeneity, and communication test results

摘要

The present disclosure provides, among other things, a method for generating and applying therapeutic interventions. The method includes, for example, (a) sequencing a polynucleotide from a subject-derived cancer cell, (b) identifying and quantifying somatic mutations in the polynucleotide, and (c) multiple in the polynucleotide. Developing a tumor heterogeneity profile in the subject indicating the presence and relative amount of somatic mutations, wherein the different relative amounts indicate tumor heterogeneity; and (d) tumor heterogeneity. Determining a therapeutic intervention for the indicated cancer, wherein the therapeutic intervention is effective for a cancer having a determined tumor heterogeneity profile.