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SMALL MOLECULE ENHANCERS FOR DENDRITIC CELL CANCER VACCINES

机译:用于树突状细胞癌疫苗的小分子增强剂

摘要

PROBLEM TO BE SOLVED: To provide methods for treating cancer, increasing anti-tumor immunity, stimulating or enhancing an immune response, treating conditions characterized by abnormal cell proliferation, increasing cytokine and/or chemokine production, or stimulating or enhancing production of T cells in mammals.;SOLUTION: Disclosed herein is a method comprising a step of administering a therapeutically effective amount of a compound that inhibits a plurality of mammalian DASH serine proteases to a mammal in need thereof. For example, the compound that inhibits a plurality of mammalian DASH serine proteases may be t-butylGly-boroPro.;SELECTED DRAWING: None;COPYRIGHT: (C)2018,JPO&INPIT
机译:要解决的问题:提供治疗癌症,增加抗肿瘤免疫力,刺激或增强免疫应答,治疗异常细胞增殖,增加细胞因子和/或趋化因子产生,或刺激或增强T细胞产生的疾病的方法。溶液:本文公开了一种方法,该方法包括将治疗有效量的抑制多种哺乳动物DASH丝氨酸蛋白酶的化合物施用于需要其的哺乳动物的步骤。例如,抑制多种哺乳动物DASH丝氨酸蛋白酶的化合物可以是叔丁基Gly-boroPro .;选择制图:无;版权:(C)2018,JPO&INPIT

著录项

  • 公开/公告号JP2017214420A

    专利类型

  • 公开/公告日2017-12-07

    原文格式PDF

  • 申请/专利权人 TRUSTEES OF TUFTS COLLEGE;

    申请/专利号JP20170159116

  • 发明设计人 WILLIAM W BACHOVCHIN;

    申请日2017-08-22

  • 分类号A61K39;A61K9/20;A61K9/48;A61K35/12;A61K35/17;A61K38;A61K38/05;A61K39/39;A61K39/395;A61K45;A61P35;A61P35/02;A61P43;A61K31/437;A61K38/14;A61K31/282;A61K31/196;A61K33/24;A61K31/7076;A61K31/4164;A61K31/337;A61K31/704;A61K31/513;A61K31/4745;A61K31/519;A61K31/573;A61K31/475;C07D471/04;C07H15/26;C07H19/173;C07D233/90;C07D305/14;C07H15/252;C07D239/553;C07D491/22;C07D475/08;C07J5;C07D519/04;

  • 国家 JP

  • 入库时间 2022-08-21 13:10:03

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