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Preservation of genomic connectivity information in fragmented genomic DNA samples
Preservation of genomic connectivity information in fragmented genomic DNA samples
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机译:片段化基因组DNA样品中的基因组连通性信息的保存
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摘要
A method of sequencing a target nucleic acid polymer by (a) modifying a target nucleic acid polymer to produce a modified nucleic acid polymer; (b) producing fragments of the modified nucleic acid polymer, wherein the fragments are attached to locations on a solid support surface (c) determining nucleotide sequences from the fragments at the locations; and (d) producing a representation of the nucleotide sequence for the target nucleic acid polymer based on the nucleotide sequences from the fragments and the relative distances between the locations on the solid support surface.
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