Preservation of genomic connectivity information in fragmented genomic DNA samples

摘要

(a) modifying the target nucleic acid polymer to produce a modified nucleic acid polymer; (b) producing a fragment of the modified nucleic acid polymer, wherein the fragment is attached to a location on the surface of the solid support; (c) the location Determining the nucleotide sequence of the fragment with (d) generating a representation of the nucleotide sequence of the target nucleic acid polymer based on the relative distance between the nucleotide sequence of the fragment and a position on the surface of the solid support. A method of sequencing a nucleic acid polymer.