Compounds and methods for the treatment of Alzheimer's disease and familial dementia

摘要

PROBLEM TO BE SOLVED: To provide protein for treating Alzheimer's disease, familial Danish dementia, and familial British dementia in mammals including human.SOLUTION: There is provided use of Bri2 (integral membrane protein 2B, ITM2B) for reducing coagulation of Aβ-peptide to amyloid fibril. Protein to be used is selected from: protein containing amino acid sequence which has at least 70% of identity to the residue of 90 to 236 of human-derived Bri2; and protein containing amino acid sequence which has at least 70% of identity to one of a Brichos domain of Bri2 derived from human, chimpanzee, bovine, swine, mouse or rat. However, isolated protein does not contain amino acid sequence having at least 70% of identity to the residue of 1 to 89 of human-derived Bri2, or to human ABri23.SELECTED DRAWING: Figure 1