METHOD FOR FULLY AUTOMATED SYNTHESIS OF 16Beta-18F-FLUORO-5Alpha-DIHYDROTESTOSTERONE (18F-FDHT)

摘要

The automated synthesis of clinically relevant amounts of 16β-¹⁸F-fluoro-5α-dihydrotestosterone (¹⁸F-FDHT) using a commercially available radiosynthesizer. Synthesis was performed in 90 minutes with a decay-corrected radiochemical yield of 29±5%. The specific activity was 4.6 Ci/μmol (170 GBq/μmol) at end of formulation with a starting activity of 1.0 Ci (37 GBq). The formulated ¹⁸F-FDHT yielded sufficient activity for multiple patient doses and passed all quality control tests required for routine clinical use.