The present invention relates to a prediction method for a mixed solvent for minimizing the amount of single solvents used, and to a system using same, and more specifically to a novel evaluation method that can predict a mixed solvent that minimizes the amount of single solvents used by using a graph-based mixing ratio dependent solubility estimation (G-MRDSE) that can calculate the maximum composition of additional solvents in a mixed solvent, and a system using same.
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