首页>
外国专利>
MULTIMERIC FUSION PROTEIN VACCINE AND IMMUNOTHERAPEUTIC
MULTIMERIC FUSION PROTEIN VACCINE AND IMMUNOTHERAPEUTIC
展开▼
机译:多元融合蛋白疫苗和免疫治疗
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present disclosure provides fusion proteins that incorporate unique mechanisms for multimerizing antigens to enhance their immunogenicity. The fusion proteins comprise at least two antigens, or other vaccine related proteins, separated by a linker sequence and an oligomerization domain. When expressed, the fusion protein forms a muKimeric protein complex, This approach can be used to muHimeri?.e a single antigen/protein or to create multimers comprising two or more different antigens/proteins. Also provided are nucleic acids encoding the fusion proteins. Yet another aspect is directed to methods of inducing or suppressing an immune response in a subject by administering to the subject a vaccine composition comprising a fusion protein or nucleic acid encoding the fusion protein, optionally without using an adjuvant.
展开▼