Iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent

摘要

Bromodomain-containing protein 4 (BRI)) has recently emerged as an attractive epigenetic target for anticancer therapy. Iridium(III) complexes are useful as irreversible inhibitor of BRD4. Complex 1a of the formula:; is particularly useful.