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Methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
Methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor
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机译:鉴定蛋白质中大分子结合和聚集倾向区域的方法及其用途
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摘要
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.
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