Substituted Hydrophobic Benzene Sulfonamide Thiazole Compounds for Use in Treating Cancer

摘要

The present invention relates to compound of general formula (I) R₁ is selected from H, aryl and alkyl, R₂ is selected from H, alkyl, aryl and CO—R₆; R₃ is selected from H, halogen, alkyl, alkenyl, alkynyl, aryl, NHR₇, NR₇R₈, OR₇ and SR₇; R₄ is selected from (C₆-C₁₂) alkyl, (C₂-C₁₂) alkenyl, (C₂-C₁₂) alkynyl and (C₆-C₁₀) aryl, R₅ represents H, R₆, aryl, OH, OR₆, O-aryl, SH, SR₆, S-aryl, CN, NO₂, CF₃, COOR₆, SO₂NR₆R₇, CONR₆R₇, NH₂, NHR₆, NH-aryl, NR₆R₇, NHCOR₆ or aminoacyl; R₆ is alkyl optionally substituted with halogen, OH, SH, NH₂, O-alkyl, S-alkyl, NH-alkyl or NH-di(alkyl); R₇ and R₈ identical or different are H or alkyl optionally substituted with halogen, OH, SH, NH₂, O-alkyl, S-alkyl, NH-alkyl or NH-di (alkyl), their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers.;