Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis

摘要

The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone or in combination by inhibiting Acyl-CoA:Cholesterol Acyltransferase 1 (ACATI) activity or expression in myeloid cells.