Benzimidazole based EGFR inhibitors

摘要

The present invention disclosed a novel EGFR inhibitor compound of formula (I), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (I).; Wherein, R═—H, 3-CH₃, 4-NO₂, 4-Cl, 2-CH₃, 4-CH₃, 4-Br, 4-FR₁═—H, -4-OCH₃, -4-NO₂,-2-NO₂, -4-Cl, -2,4,6-CH₃, -4-CH₃, -2-F,4-Br, -4-CF₃, -4-S—CH₃, -4-Cl,-3-CF₃, -3-S—CH₃, -3,5-CF₃, -2-S—CH₃, -3-CF₃,-4-OCF₃, —Si—(CH₃)₃, —Si—(C₂H₅)₃, (CH₃)₂—Si— C₂H₅.