The method of obtaining with L-asparaginase recombinant low molar mass, with L-asparaginase and use of the same recombinant

摘要

The method of obtaining with L-asparaginase recombinant low molar mass, with L-asparaginase recombinant and use of the same.This invention describes a method of obtaining a recombinant with L-asparaginase, as well as the enzyme and its potential use in preparation of medicines for treating various types of cancer.In addition to leukaemic malignancies.The method of the present invention was obtained according to the methodologies of molecular biology and the recombinant enzyme obtained is an L - asnase yeast low molar mass and, therefore,Presents low immunogenic activity and high specific activity of asparagine, and may be combined with the peg in the cisteu00ednas or amino acids containing amino groups in the side chain.