compounds, pharmaceutical composition, uses of a compound or a pharmaceutically acceptable salt thereof for the treatment of a host infected with a human papillomavirus, uses of a compound, method for the manufacture of a medicament for therapeutic use in the treatment of a papillomavirus infection

摘要

Acyclic nucleotide analogs and methods of using an acyclic nucleotide analog for the treatment and / or amelioration of a papillomavirus infection are disclosed in the present invention. In one embodiment, the invention describes compounds with antiviral activity against a papillomavirus in the absence of a significant host cell antiproliferative effect. therefore, the present invention includes antiviral agents that selectively inhibit and / or block viral DNA synthesis and / or virion production of high risk hpv types.