chimeric proteins isolated from modified lumazine synthase

摘要

chimeric proteins isolated from modified lumazine synthase. The present invention relates to isolated chimeric proteins including up to ten copies of peptides, polypeptides or protein domains inserted into the amino terminus of brucella spp. to lumazine synthase enzyme. to nucleotide sequences encoding the chimeric proteins. to vectors, plasmids and transformed cells used for protein expression. to monoclonal and polyclonal antibodies induced by chimeric proteins. to hybridomas that produce monoclonal antibodies. vaccines and pharmaceutical compounds including chimeric proteins, nucleotide sequences and antibodies. to a method for inducing an immune response in higher organisms including administration of effective amounts of vaccines and pharmaceutical compounds. biosensors including chimeric proteins. to protein conjugates formed by the chimeric proteins and a ligand linked by covalent and noncovalent bonds. the uses of chimeric proteins, nucleotide sequences, vectors, plasmids, transformed cells, antibodies, hybridomas, conjugates, biosensors, vaccines, and pharmaceutical compounds. quaternary structure of chimeric proteins.